Octanoic acid
Octanoic acid is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target hydroxycarboxylic acid receptor 3 and cytochrome P450 4Z1.
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Clinical
Clinical Trials
81 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Primary immunodeficiency diseases | D000081207 | — | — | — | 1 | 3 | 2 | 1 | 7 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 1 | 1 | — | 1 | 2 | 5 |
| Immunologic deficiency syndromes | D007153 | — | D84.9 | — | 1 | 1 | 2 | 1 | 5 |
| Chronic inflammatory demyelinating polyradiculoneuropathy | D020277 | EFO_1000868 | G61.81 | — | — | 1 | 1 | — | 2 |
| Streptococcal infections | D013290 | EFO_1001476 | — | — | — | — | 1 | — | 1 |
| Staphylococcal infections | D013203 | — | A49.01 | — | — | — | 1 | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | — | 1 |
| Immune system diseases | D007154 | — | D89.9 | — | — | — | 1 | — | 1 |
| Peripheral nervous system diseases | D010523 | — | G64 | — | — | — | 1 | — | 1 |
| Stomatitis | D013280 | EFO_1001904 | K12.1 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Myasthenia gravis | D009157 | EFO_0004991 | G70.0 | — | 1 | 1 | — | — | 2 |
| Muscle weakness | D018908 | — | — | — | 1 | 1 | — | — | 2 |
| Agammaglobulinemia | D000361 | — | D80.1 | — | 1 | 1 | — | — | 2 |
| Wiskott-aldrich syndrome | D014923 | EFO_0003903 | D82.0 | — | — | 1 | — | — | 1 |
| Severe combined immunodeficiency | D016511 | — | D81.0 | — | — | 1 | — | — | 1 |
| Common variable immunodeficiency | D017074 | EFO_0000367 | D83 | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Leukemia | D007938 | — | C95 | 3 | 1 | — | — | — | 4 |
| Syndrome | D013577 | — | — | 1 | 3 | — | — | 1 | 4 |
| Gastroparesis | D018589 | EFO_1000948 | K31.84 | — | 2 | — | — | 2 | 4 |
| Recurrence | D012008 | — | — | 4 | 1 | — | — | — | 4 |
| Myelodysplastic syndromes | D009190 | — | D46 | 1 | 3 | — | — | — | 3 |
| Myeloid leukemia acute | D015470 | — | C92.0 | 2 | 2 | — | — | — | 3 |
| Preleukemia | D011289 | — | — | 1 | 3 | — | — | — | 3 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 2 | 1 | — | — | — | 3 |
| Essential tremor | D020329 | EFO_0003108 | G25.0 | 3 | 2 | — | — | — | 3 |
| Tremor | D014202 | — | R25.1 | 3 | 2 | — | — | — | 3 |
Show 31 more
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 4 | — | — | — | 3 | 7 |
| Pancreatic ductal carcinoma | D021441 | — | — | 2 | — | — | — | — | 2 |
| Acinar cell carcinoma | D018267 | — | — | 2 | — | — | — | — | 2 |
| Mycoses | D009181 | — | B35-B49 | 2 | — | — | — | — | 2 |
| Non-hodgkin lymphoma | D008228 | — | C85.9 | 2 | — | — | — | — | 2 |
| Lymphoma | D008223 | — | C85.9 | 2 | — | — | — | — | 2 |
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | — | C91.0 | 2 | — | — | — | — | 2 |
| Sezary syndrome | D012751 | — | C84.1 | 2 | — | — | — | — | 2 |
| Biphenotypic leukemia acute | D015456 | — | C95.0 | 2 | — | — | — | — | 2 |
| Mycosis fungoides | D009182 | — | C84.0 | 2 | — | — | — | — | 2 |
Show 37 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ketosis | D007662 | — | R82.4 | — | — | — | — | 2 | 2 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | — | — | — | 2 | 2 |
| Aging | D000375 | GO_0007568 | R41.81 | — | — | — | — | 1 | 1 |
| Satiety response | D012528 | — | — | — | — | — | — | 1 | 1 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | — | — | — | 1 | 1 |
| Gastric emptying | D005746 | — | — | — | — | — | — | 1 | 1 |
| Hypoglycemia | D007003 | — | E16.2 | — | — | — | — | 1 | 1 |
| Diabetic foot | D017719 | EFO_1001459 | — | — | — | — | — | 1 | 1 |
| Skin abnormalities | D012868 | — | Q82.9 | — | — | — | — | 1 | 1 |
| Guillain-barre syndrome | D020275 | EFO_0007292 | G61.0 | — | — | — | — | 1 | 1 |
Show 7 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Octanoic acid |
| INN | octanoic acid |
| Description | Octanoic acid is a straight-chain saturated fatty acid that is heptane in which one of the hydrogens of a terminal methyl group has been replaced by a carboxy group. Octanoic acid is also known as caprylic acid. It has a role as an antibacterial agent, a human metabolite and an Escherichia coli metabolite. It is a straight-chain saturated fatty acid and a medium-chain fatty acid. It is a conjugate acid of an octanoate. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CCCCCCCC(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 124-07-2 |
| RxCUI | — |
| ChEMBL ID | CHEMBL324846 |
| ChEBI ID | 28837 |
| PubChem CID | 379 |
| DrugBank | DB04519 |
| UNII ID | OBL58JN025 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
HCAR3
HCAR3
CYP4Z1
CYP4Z1
Organism
Homo sapiens
Gene name
HCAR3
Gene synonyms
GPR109B, HCA3, HM74B, NIACR2
NCBI Gene ID
Protein name
hydroxycarboxylic acid receptor 3
Protein synonyms
G-protein coupled receptor 109B, G-protein coupled receptor HM74, G-protein coupled receptor HM74B, GTP-binding protein, hydroxy-carboxylic acid receptor 3, Niacin receptor 2, Nicotinic acid receptor 2, putative chemokine receptor
Uniprot ID
Mouse ortholog
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Variants
No data
Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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22 adverse events reported
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